Last data update: May 06, 2024. (Total: 46732 publications since 2009)
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Query Trace: Gmez GA[original query] |
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Burden of Diarrheagenic Escherichia coli in Santa Rosa, Guatemala in active health-services surveillance during 2008-2009 and 2014-2015.
Jarquin C , Morales O , McCracken JP , Lopez MR , Lopez B , Reyes L , Gmez GA , Bryan JP , Peruski LF , Pattabiraman V , Parsons MB . Trop Med Int Health 2022 27 (4) 408-417 OBJECTIVE: To describe the epidemiology of laboratory-confirmed Diarrheagenic Escherichia coli (DEC) cases from active facility-based surveillance in Guatemala. METHODS: We collected clinical and risk factor data on enrolled patients (aged 0-52 years) with acute diarrhea at government healthcare facilities (1 hospital and 6 clinics) in Santa Rosa, Guatemala, during 2008-2009 and 2014-2015. Stool samples were analyzed and E. coli identified through culture and biochemical tests, PCR amplification of genes encoding pathotype-specific virulence factors identified specific DEC pathotypes. Healthcare-seeking adjusted incidence rates were calculated. RESULTS: 3041 diarrhea cases were captured by surveillance (647 hospitalizations (H), 2394 clinic visits (CV)); general E. coli prevalence was 17.9%. DEC pathotypes were identified in 19% (n=95/497) and 21% (n=450/2113) in diarrhea H and CV, respectively. Enteropathogenic E. coli (EPEC) was most frequently isolated (8.2% (n=41) in diarrhea H, 12.0% (n =255) in diarrhea CV), followed by ETEC (6.8% (n=34) in H, 6% (n=128) in CV) and STEC (0.6% (n=3) in H, 0.6% (n=13) in CV). We did not find evidence of a difference in severity between DEC and non-DEC diarrhea. Incidence of DEC clinic visits and hospitalizations was 648.0 and 29.3, respectively, per 10,000 persons aged 5 years and 36.8 and 0.4, respectively, per 10,000 persons aged >5 years. CONCLUSIONS: DEC pathotypes, especially EPEC and ETEC, were detected frequently from patients presenting with diarrheal illness in Santa Rosa, Guatemala. Our findings suggest that preventive interventions should be prioritized for young children. |
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